Article
The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis.
PloS one - 23 Feb 2011
Xue Jianmin, Gochuico Bernadette R, Alawad Ahmad Samer, Feghali-Bostwick Carol A, Noth Imre, Nathan Steven D, Rosen Glenn D, Rosas Ivan O, Dacic Sanja, Ocak Iclal, Fuhrman Carl R, Cuenco Karen T, Smith Mary A, Jacobs Susan S, Zeevi Adriana, Morel Penelope A, Pilewski Joseph M, Valentine Vincent G, Gibson Kevin F, Kaminski Naftali, Sciurba Frank C, Zhang Yingze, Duncan Steven R
Abstract excerpt
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and medically refractory lung disease with a grim prognosis. Although the etiology of IPF remains perplexing, abnormal adaptive immune responses are evident in many afflicted patients. We hypothesized that perturbations of human leukocyte antigen (HLA) allele frequencies, which are often seen among patients with immunologic diseases, may also be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.