Article
Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.
BMC genetics - 7 Jun 2016
Fingerlin Tasha E, Zhang Weiming, Yang Ivana V, Ainsworth Hannah C, Russell Pamela H, Blumhagen Rachel Z, Schwarz Marvin I, Brown Kevin K, Steele Mark P, Loyd James E, Cosgrove Gregory P, Lynch David A, Groshong Steve, Collard Harold R, Wolters Paul J, Bradford Williamson Z, Kossen Karl, Seiwert Scott D, du Bois Roland M, Garcia Christine Kim, Devine Megan S, Gudmundsson Gunnar, Isaksson Helgi J, Kaminski Naftali, Zhang Yingze, Gibson Kevin F, Lancaster Lisa H, Maher Toby M, Molyneaux Philip L, Wells Athol U, Moffatt Miriam F, Selman Moises, Pardo Annie, Kim Dong Soon, Crapo James D, Make Barry J, Regan Elizabeth A, Walek Dinesha S, Daniel Jerry J, Kamatani Yoichiro, Zelenika Diana, Murphy Elissa, Smith Keith, McKean David, Pedersen Brent S, Talbert Janet, Powers Julia, Markin Cheryl R, Beckman Kenneth B, Lathrop Mark, Freed Brian, Langefeld Carl D, Schwartz David A
Abstract excerpt
BACKGROUND: Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10...
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