Article
Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2011
Dey Madhusudan, Velyvis Algirdas, Li John J, Chiu Elaine, Chiovitti David, Kay Lewis E, Sicheri Frank, Dever Thomas E
Abstract excerpt
As phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) on Ser51 inhibits protein synthesis, cells restrict this phosphorylation to the antiviral protein kinase PKR and related eIF2α kinases. In the crystal structure of the PKR-eIF2α complex, the C-terminal lobe of the kinase contacts eIF2α on a face remote from Ser51, leaving Ser51 ∼ 20 Å from the kinase active site. PKR mutations that cripple...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.