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Article

P-Glycoprotein (ABCB1) expression in human skin is mainly restricted to dermal components

1 Mar 2011

Abstract excerpt

Several transport proteins are constitutively expressed in skin cells, but the putative role of the ABC transporter P-glycoprotein (P-gp) in human skin is yet unknown. Therefore, we analysed mRNA and protein expression and localization of P-gp in human skin. Using qRT-PCR, we demonstrated a strong MDR1 mRNA expression in whole skin specimens and dermis, whereas the expression of MDR1 in epidermis, epidermal...

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PMID: 21366702
DOI: 10.1111/j.1600-0625.2010.01237.x

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