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Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin

31 Oct 2020

Abstract excerpt

ABC transporters (ATP-binding cassette transporter) traffic drugs and their metabolites across membranes, making ABC transporter expression levels a key factor regulating local drug concentrations in different tissues and individuals. Yet, quantification of ABC transporters remains challenging because they are large and low-abundance transmembrane proteins. Here, we analysed 200 samples of crude and...

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PMID: 33128234
DOI: 10.1002/1873-3468.13982

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