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Article

Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1

25 Feb 2011

Abstract excerpt

DSCR1/ RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down syndrome (DS) and postulated as a good candidate to contribute to mental disability. However, even though Rcan1 knockout mice have pronounced spatial learning and memory deficits, the possible deleterious effects of its overexpression in DS are not well understood. We have generated a transgenic mouse model overexpressing...

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PMID: 21364922
DOI: 10.1371/journal.pone.0017010

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