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Article

The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation.

Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2003

Chang Karen T, Shi Yi-Jun, Min Kyung-Tai

Abstract excerpt

Mental retardation is the most common phenotypic abnormality seen in Down's syndrome (DS) patients, yet the underlying mechanism remains mysterious. DS critical region 1 (DSCR1), located on chromosome 21, is overexpressed in the brain of DS fetus and encodes an inhibitor of calcineurin, but its physiological significance is unknown. To study its functional importance and role in mental retardation in DS, we...

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Identifiers

PMID: 14668437
DOI: 10.1073/pnas.2536696100
PMCID: PMC307647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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