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Article

Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse

1 Jan 2007

Abstract excerpt

BACKGROUND: Hereditary hemochromatosis (HH) encompasses genetic disorders of iron overload characterized by deficient expression or function of the iron-regulatory hormone hepcidin. Mutations in 5 genes have been linked to this disease: HFE, TFR2 (encoding transferrin receptor 2), HAMP (encoding hepcidin), SLC40A1 (encoding ferroportin) and HJV (encoding hemojuvelin). Hepcidin inhibits iron export from cells into...

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PMID: 17949489
DOI: 10.1186/1471-2164-8-379

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