Biosynthesis of the polysialic acid capsule in Escherichia coli K1. Cold inactivation of sialic acid synthase regulates capsule expression below 20 degrees C.

doi:10.1093/glycob/1.1.93

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Article

Biosynthesis of the polysialic acid capsule in Escherichia coli K1. Cold inactivation of sialic acid synthase regulates capsule expression below 20 degrees C.

Glycobiology - 1 Sept 1990

Merker R I, Troy F A

Abstract excerpt

When neuroinvasive Escherichia coli K1 cells are grown at temperatures below 20 degrees C, they fail to synthesize the alpha-2,8-linked polysialic acid (polySia) capsule. The objective of this study was to use a genetic and biochemical approach to analyse why capsule expression was defective at c...

Topics

Carbon Radioisotopes
Escherichia coli
Freezing
Genotype
Kinetics
Oxo-Acid-Lyases
Sialic Acids
Thermodynamics

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