Reduced polysialic acid capsule expression in Escherichia coli K1 mutants with chromosomal defects in kpsF.

doi:10.1046/j.1365-2958.1997.5651942.x

Back to search

Article

Reduced polysialic acid capsule expression in Escherichia coli K1 mutants with chromosomal defects in kpsF.

Molecular microbiology - 1 Oct 1997

Cieslewicz M, Vimr E

Abstract excerpt

Neuroinvasive Escherichia coli K1 synthesizes and assembles a polysialic acid capsule virulence factor on the external leaflet of the outer membrane. This capsule functions in pathogenesis by blocking non-immune host defence mechanisms and acting as a relatively non-immunogenic molecular mimic of...

Topics

Bacterial Proteins
Chromosomes, Bacterial
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Humans
Mutation
Polysaccharides, Bacterial
Sialic Acids

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.