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Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children.

Microbiology and immunology - 1 May 2011

Tanaka Kaori, Hori Tsukasa, Yoto Yuko, Hatakeyama Naoki, Yamamoto Masaki, Suzuki Nobuhiro, Tsutsumi Hiroyuki

Abstract excerpt

There is no existing data on UL97 mutation in human cytomegalovirus (HCMV) isolates obtained from individuals who have never been exposed to ganciclovir (GCV). UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a...

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PMID: 21362026
DOI: 10.1111/j.1348-0421.2011.00327.x

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