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Article

Mechanistic, mutational, and structural evaluation of a Taxus phenylalanine aminomutase.

Biochemistry - 12 Apr 2011

Feng Lei, Wanninayake Udayanga, Strom Susan, Geiger James, Walker Kevin D

Abstract excerpt

The structure of a phenylalanine aminomutase (TcPAM) from Taxus canadensis has been determined at 2.4 Å resolution. The active site of the TcPAM contains the signature 4-methylidene-1H-imidazol-5(4H)-one prosthesis, observed in all catalysts of the class I lyase-like family. This catalyst isomerizes (S)-α-phenylalanine to the (R)-β-isomer by exchange of the NH2/H pair. The stereochemistry of the TcPAM reaction...

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PMID: 21361343
DOI: 10.1021/bi102067r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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