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Article

A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer.

BMC systems biology - 26 Feb 2011

Nagaraj Shivashankar H, Reverter Antonio

Abstract excerpt

BACKGROUND: Cancer has remarkable complexity at the molecular level, with multiple genes, proteins, pathways and regulatory interconnections being affected. We introduce a systems biology approach to study cancer that formally integrates the available genetic, transcriptomic, epigenetic and molecular knowledge on cancer biology and, as a proof of concept, we apply it to colorectal cancer. RESULTS: We first...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21352556
DOI: 10.1186/1752-0509-5-35
PMCID: PMC3051904

Genes

CDK8
EPHB3
FXYD1
TRPM6
ZIC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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