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Article

A systems genomics approach to uncover the molecular properties of cancer genes.

Scientific reports - 27 Oct 2020

Grassmann Felix, Pawitan Yudi, Czene Kamila

Abstract excerpt

Genes involved in cancer are under constant evolutionary pressure, potentially resulting in diverse molecular properties. In this study, we explore 23 omic features from publicly available databases to define the molecular profile of different classes of cancer genes. Cancer genes were grouped according to mutational landscape (germline and somatically mutated genes), role in cancer initiation (cancer driver...

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PMID: 33110144
DOI: 10.1038/s41598-020-75400-2
PMCID: PMC7591476

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