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Article

Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.

Biochemistry - 12 Apr 2011

Gift Syna Kuriakose, Zentner Isaac J, Schön Arne, McFadden Karyn, Umashankara M, Rajagopal Srivats, Contarino Mark, Duffy Caitlin, Courter Joel R, Zhang Mei-Yun, Gershoni Jonathan M, Cocklin Simon, Dimitrov Dimiter S, Smith Amos B, Freire Ernesto, Chaiken Irwin M

Abstract excerpt

We investigated the interaction between cross-reactive HIV-1 neutralizing human monoclonal antibody m18 and HIV-1YU-2 gp120 in an effort to understand how this antibody inhibits the entry of virus into cells. m18 binds to gp120 with high affinity (KD≈5 nM) as measured by surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC). SPR analysis further showed that m18 inhibits interactions of gp120...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21351734
DOI: 10.1021/bi101160r
PMCID: PMC3088361

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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