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Article

HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.

Proteins - 1 Feb 2013

Tuzer Ferit, Madani Navid, Kamanna Kantharaju, Zentner Isaac, LaLonde Judith, Holmes Andrew, Upton Elizabeth, Rajagopal Srivats, McFadden Karyn, Contarino Mark, Sodroski Joseph, Chaiken Irwin

Abstract excerpt

Despite advances in HIV therapy, viral resistance and side-effects with current drug regimens require targeting new components of the virus. Dual antagonist peptide triazoles (PT) are a novel class of HIV-1 inhibitors that specifically target the gp120 component of the viral spike and inhibit its interaction with both of its cell surface protein ligands, namely the initial receptor CD4 and the co-receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23011758
DOI: 10.1002/prot.24184
PMCID: PMC3731144

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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