Article
The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.
PloS one - 9 Feb 2011
Vandevenne Patricia, Lebrun Marielle, El Mjiyad Nadia, Ote Isabelle, Di Valentin Emmanuel, Habraken Yvette, Dortu Estelle, Piette Jacques, Sadzot-Delvaux Catherine
Abstract excerpt
The innate immune response constitutes the first line of host defence that limits viral spread and plays an important role in the activation of adaptive immune response. Viral components are recognized by specific host pathogen recognition receptors triggering the activation of IRF3. IRF3, along with NF-κB, is a key regulator of IFN-β expression. Until now, the role of IRF3 in the activation of the innate immune...
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