Article

Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion

2019-09-02

Abstract excerpt

Expanded CAG/CTG repeats underlie thirteen neurological disorders, including myotonic dystrophy (DM1) and Huntington’s disease (HD). Upon expansion, CAG/CTG repeat loci acquire heterochromatic characteristics. This observation raises the hypothesis that repeat expansion provokes changes to higher order chromatin folding and thereby affects both gene expression in cis and the genetic instability of the repeat trac...

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Literature Corpus work: 789d57f5-64b4-52e6-b5da-c870130eecf6
DOI: 10.1101/754838

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