Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2.

doi:10.1038/clpt.1990.34

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Article

Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2.

Clinical pharmacology and therapeutics - 1 Mar 1990

Yasumori T, Murayama N, Yamazoe Y, Kato R

Abstract excerpt

Stereoselective 4'-hydroxylations of R-(-)-mephenytoin and S-(+)-mephenytoin and 3'-hydroxylation of R-(-)-hexobarbital and S-(+)-hexobarbital were determined in liver microsomes of 14 Japanese subjects who were extensive metabolizers of mephenytoin and in five Japanese subjects who were poor met...

Topics

Cytochrome P-450 Enzyme System
Hexobarbital
Humans
Hydantoins
Hydroxylation
Mephenytoin
Microsomes, Liver
Mixed Function Oxygenases
Phenotype
Polymorphism, Genetic
Stereoisomerism

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