Article

Opposing roles of blood-borne monocytes and tissue-resident macrophages in limbal stem cell damage after ocular injury

2021-07-26

Abstract excerpt

Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed that this is mediated directly by the caustic agent. Here we show that LSC damage occurs through immune cell mediators, even without direct injury to LSCs. In particular, pH elevation in the anterior chamber (AC) causes acute uveal stress, release of inflammatory cytokines at the...

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Literature Corpus work: 8df1dad2-0b7b-5ee2-a817-587798b1d00a
DOI: 10.1101/2021.07.25.453707

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