Article
GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.
Development (Cambridge, England) - 1 Jan 2007
Zhang Yuzhen, Rath Nibedita, Hannenhalli Sridhar, Wang Zhishan, Cappola Thomas, Kimura Shioko, Atochina-Vasserman Elena, Lu Min Min, Beers Michael F, Morrisey Edward E
Abstract excerpt
In vitro studies have suggested that members of the GATA and Nkx transcription factor families physically interact, and synergistically activate pulmonary epithelial- and cardiac-gene promoters. However, the relevance of this synergy has not been demonstrated in vivo. We show that Gata6-Titf1 (Gata6-Nkx2.1) double heterozygous (G6-Nkx DH) embryos and mice have severe defects in pulmonary epithelial...
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