Article
Improved NADPH supply for xylitol production by engineered Escherichia coli with glycolytic mutations.
Biotechnology progress - 1 Jan 2000
Chin Jonathan W, Cirino Patrick C
Abstract excerpt
Escherichia coli engineered to uptake xylose while metabolizing glucose was previously shown to produce high levels of xylitol from a mixture of glucose and xylose when expressing NADPH-dependent xylose reductase from Candida boidinii (CbXR) (Cirino et al., Biotechnol Bioeng. 2006;95:1167-1176). We then described the effects of deletions of key metabolic pathways (e.g., Embden-Meyerhof-Parnas and pentose...
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