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Article

Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors.

Oncogene - 23 Jun 2011

Dettman E J, Simko S J, Ayanga B, Carofino B L, Margolin J F, Morse H C, Justice M J

Abstract excerpt

Understanding the heterogeneous genetic mechanisms of tumor initiation in lymphoid leukemias (LL) will lead to improvements in prognostic classification and treatment regimens. In previous studies of mouse leukemias, we showed that retroviral insertion at the ecotropic viral insertion site 32 locus leads to increased expression of Prdm14, a pluripotency gene implicated in the self-renewal capacity of embryonic...

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Identifiers

PMID: 21339739
DOI: 10.1038/onc.2011.12
PMCID: PMC3121925

Genes

PRDM14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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