Article
Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae.
The Journal of clinical investigation - 1 Mar 2011
Chassaing Benoit, Rolhion Nathalie, de Vallée Amélie, Salim Sa'ad Y, Prorok-Hamon Maelle, Neut Christel, Campbell Barry J, Söderholm Johan D, Hugot Jean-Pierre, Colombel Jean-Frédéric, Darfeuille-Michaud Arlette
Abstract excerpt
Crohn disease (CD) is a multifactorial disease in which an abnormal immune response in the gastrointestinal (GI) tract leads to chronic inflammation. The small intestine, particularly the ileum, of patients with CD is colonized by adherent-invasive E. coli (AIEC)--a pathogenic group of E. coli able to adhere to and invade intestinal epithelial cells. As the earliest inflammatory lesions are microscopic erosions...
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