Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner

21 Feb 2011

Abstract excerpt

Changes of the microtubule-associated protein tau are central in Alzheimer's disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). However, the functional consequence of the FTDP-17 tau mutation R406W, which causes a tauopathy clinically resembling AD, is not well understood. We find that the R406W mutation does not affect microtubule interaction but abolishes tau's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Computational Drug Discovery Methods
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21339331
DOI: 10.1083/jcb.201007161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent mannerPMID 21339331Read ↗

ANXA2 Protein and Its Role in Neurodegeneration ProcessesSemantic proximity Read ↗

ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics.Semantic proximity Read ↗

The FTDP‐17‐Linked Mutation R406W Abolishes the Interaction of Phosphorylated Tau with MicrotubulesSemantic proximity Read ↗

Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative diseaseSemantic proximity Read ↗

Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defectsSemantic proximity Read ↗

Calcium as a molecular switch that regulates Annexin A11 N- and C-terminal domains interaction and its role in ALS.Semantic proximity Read ↗

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.Semantic proximity Read ↗

Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations.Semantic proximity Read ↗

Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron diseaseSemantic proximity Read ↗

Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies.Semantic proximity Read ↗

Direct interactions of adaptor protein complexes 1 and 2 with the copper transporter ATP7A mediate its anterograde and retrograde trafficking.Semantic proximity Read ↗

Structural and microtubule binding properties of tau mutants of frontotemporal dementias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.