Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.

doi:10.1371/journal.pone.0059230

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Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.

PloS one - 1 Jan 2013

Lan Qing, Cawthon Richard, Gao Yutang, Hu Wei, Hosgood H Dean, Barone-Adesi Francesco, Ji Bu-Tian, Bassig Bryan, Chow Wong-Ho, Shu Xiaoou, Cai Qiuyin, Xiang Yongbin, Berndt Sonja, Kim Christopher, Chanock Stephen, Zheng Wei, Rothman Nathaniel

Abstract excerpt

A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma of the lung. The telomerase gene TERT is a reverse transcriptase that is critical for telomere replication and stabilization by controlling telomere length. We...

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PMID: 23555636
DOI: 10.1371/journal.pone.0059230
PMCID: PMC3608613

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TERT

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