Article
A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
Human genetics - 1 Feb 2007
Ingram Catherine J E, Elamin Mohamed F, Mulcare Charlotte A, Weale Michael E, Tarekegn Ayele, Raga Tamiru Oljira, Bekele Endashaw, Elamin Farouk M, Thomas Mark G, Bradman Neil, Swallow Dallas M
Abstract excerpt
Persistence or non-persistence of lactase expression into adult life is a polymorphic trait that has been attributed to a single nucleotide polymorphism (C-13910T) in an enhancer element 13.9 kb upstream of the lactase gene (LCT). The -13910*T allele occurs at very high frequency in northern Europeans as part of a very long haplotype (known as A), and promotes binding of the transcription factor Oct-1. However,...
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