Article
Mutation spectrum, expression profiling, and prognosis evaluation of Fanconi anemia signaling pathway genes for 4259 patients with myelodysplastic syndromes or acute myeloid leukemia.
BMC medical genomics - 16 Nov 2023
Chang Lixian, Zhang Li, Zhao Beibei, Cheng Xuelian, Wan Yang, Zhang Ranran, Yuan Weiping, Gao Xingjie, Zhu Xiaofan
Abstract excerpt
BACKGROUND: Individuals diagnosed with Fanconi anemia (FA), an uncommon disorder characterized by chromosomal instability affecting the FA signaling pathway, exhibit heightened vulnerability to the onset of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). METHODS: Herein, we employed diverse bioinformatics and statistical analyses to investigate the potential associations between the...
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