Article
Molecular Cytogenetic Approach to Characterize Novel and Cryptic Chromosome Abnormalities in Childhood Myeloid Malignances of Fanconi Anemia.
Journal of pediatric hematology/oncology - 1 Mar 2017
Borges Maria L R, Capela de Matos Roberto R, Amaral Bethânia D A Silva, Soares-Ventura Eliane M, Leite Edinalva P, Silva Mariluze O D, Cornélio Maria T M Nogueira, Silva Maria L M, Liehr Thomas, Marques-Salles Terezinha D J
Abstract excerpt
Myeloid malignancies can be either primary or secondary, whether or not a specific cause can be determined. Fanconi anemia (FA), a rare constitutional bone marrow failure, usually presents an increased possibility of clonal evolution, due to the increase in chromosomal instability, TP53 activation, and cell death. The evolution of FA may include aplastic anemia by the progressive failure of the bone marrow and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.