Article
Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML.
Pediatric blood & cancer - 1 Nov 2012
Rochowski Andrzej, Olson Susan B, Alonzo Todd A, Gerbing Robert B, Lange Beverly J, Alter Blanche P
Abstract excerpt
Specific cytogenetic clones might distinguish patients with unrecognized Fanconi anemia (FA) who present with acute myeloid leukemia (AML) from those with sporadic AML. Cytogenetic reports in literature cases of FA and AML were compared with de novo cases enrolled on CCG-2961. Gain of 1q, gain of 3q, monosomy 7, deleted 7q, gain of 13q, and deleted 20q were more frequent in FA AML; t(8;21), trisomy 8, t(9;11),...
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