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Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

1 Jun 2018

Abstract excerpt

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy caused by somatically acquired changes affecting a well-defined set of genes 1 . While rare high-risk variants affecting specific transcription factors account for a proportion of myelodysplastic syndrome (MDS) and AML associated with a family history, the contribution of other germline variants conferring low-intermediate risk has not yet...

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PMID: 29891941
DOI: 10.1038/s41408-018-0090-7

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