Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart

1 Mar 2012

Abstract excerpt

Heart failure is a leading cause of death worldwide. Estrogen-related receptors (ERRs) are a nuclear receptor subfamily that facilitates the transcription of contractile and nucleus-encoded mitochondrial genes in the heart. Impaired expression of these ERR target genes is frequently observed in human heart failure patients. However, the responsible molecular mechanism is not well-understood. Recently, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to PARP inhibition in cancer therapy
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22333581
DOI: 10.4161/cc.11.5.19210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heartPMID 22333581Read ↗

PGC-1α and ERRα target gene downregulation is a signature of the failing human heartSemantic proximity Read ↗

Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophySemantic proximity Read ↗

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesisSemantic proximity Read ↗

Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overloadSemantic proximity Read ↗

Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4.Semantic proximity Read ↗

Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac HypertrophySemantic proximity Read ↗

The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophySemantic proximity Read ↗

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigeneticsSemantic proximity Read ↗

Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks.Semantic proximity Read ↗

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in miceSemantic proximity Read ↗

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failureSemantic proximity Read ↗

Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than malesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.