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Article

Galactose induction of the GAL1 gene requires conditional degradation of the Mig2 repressor.

The Biochemical journal - 1 May 2011

Lim Mei Kee, Siew Wee Leng, Zhao Jin, Tay Ywee Chieh, Ang Edwin, Lehming Norbert

Abstract excerpt

Skp1 an essential component of the SCF (Skp1/cullin/F-box) E3 ubiquitin ligases, which target proteins for degradation by the 26S proteasome. We generated a skp1dM mutant strain that is defective for galactose induction of the GAL1 gene and we have found that galactose-induced protein degradation of the repressor Mig2 is defective in this strain. Mig2 degradation was also abolished in cells lacking the protein...

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Identifiers

PMID: 21323640
DOI: 10.1042/BJ20102034

Genes

GAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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