Article
TGF-β1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNAI2/Slug.
The Prostate - 1 Sept 2011
Slabáková Eva, Pernicová Zuzana, Slavíčková Eva, Staršíchová Andrea, Kozubík Alois, Souček Karel
Abstract excerpt
BACKGROUND: Epithelial-mesenchymal transition (EMT) underlying cancer cell invasion and metastasis has been thoroughly studied in prostate cancer. Although EMT markers have been clinically observed in benign prostate hyperplasia, molecular events underlying the onset and progression of EMT in benign prostate cells have not been described. METHODS: EMT in BPH-1 cells was induced by TGF-β1 treatment and the...
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