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Article

Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter.

PLoS pathogens - 1 Feb 2011

Petter Michaela, Lee Chin Chin, Byrne Timothy J, Boysen Katja E, Volz Jennifer, Ralph Stuart A, Cowman Alan F, Brown Graham V, Duffy Michael F

Abstract excerpt

Plasmodium falciparum employs antigenic variation to evade the human immune response by switching the expression of different variant surface antigens encoded by the var gene family. Epigenetic mechanisms including histone modifications and sub-nuclear compartmentalization contribute to transcriptional regulation in the malaria parasite, in particular to control antigenic variation. Another mechanism of...

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PMID: 21379342
DOI: 10.1371/journal.ppat.1001292
PMCID: PMC3040674

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Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter.PMID 21379342Read ↗

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