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Article

The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.

Neuroscience letters - 27 Oct 2000

Mellick G D, Silburn P A

Abstract excerpt

The ubiquitin carboxy-terminal hydrolase L1gene (UCH-L1) has been implicated in the aetiology of Parkinson's disease (PD). A rare Ile93Met mutation in UCH-L1 in a German PD sib-pair has been reported. Recently, a S18Y (C54A) polymorphism in exon 3 of UCH-L1 was found to be under-represented in PD patients compared to controls. To test the reproducibility of this negative association, we conducted an...

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PMID: 11027850
DOI: 10.1016/s0304-3940(00)01510-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.PMID 11027850Read ↗

Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.Semantic proximity Read ↗

Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymorphism and PDSemantic proximity Read ↗

No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease.Semantic proximity Read ↗

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.Semantic proximity Read ↗

Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease.Semantic proximity Read ↗

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.Semantic proximity Read ↗

Lack of evidence for association of a UCH-L1 S18Y polymorphism with Parkinson's disease in a Han-Chinese population.Semantic proximity Read ↗

S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.Semantic proximity Read ↗

UCHL1 is a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population.Semantic proximity Read ↗

Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Semantic proximity Read ↗

UCHL-1 is not a Parkinson's disease susceptibility gene.Semantic proximity Read ↗

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