Article
Sodium ion channel mutations in glioblastoma patients correlate with shorter survival.
Molecular cancer - 11 Feb 2011
Joshi Avadhut D, Parsons D Williams, Velculescu Victor E, Riggins Gregory J
Abstract excerpt
BACKGROUND: Glioblastoma Multiforme (GBM) is the most common and invasive astrocytic tumor associated with dismal prognosis. Treatment for GBM patients has advanced, but the median survival remains a meager 15 months. In a recent study, 20,000 genes from 21 GBM patients were sequenced that identified frequent mutations in ion channel genes. The goal of this study was to determine whether ion channel mutations...
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