Article
Comparison of multiplex restriction fragment mass polymorphism and sequencing analyses for detecting entecavir resistance in chronic hepatitis B.
Antiviral therapy - 1 Jan 2011
Han Kyung Ho, Hong Sun Pyo, Choi Seo Hee, Shin Soo-Kyung, Cho Sung Won, Ahn Sang Hoon, Hahn Ji-Sook, Kim Soo-Ok
Abstract excerpt
BACKGROUND: Drug resistance is a major limitation to the long-term efficacy of controlling chronic hepatitis B (CHB). There is a growing need to analyse multiple mutations associated with drug resistance because sequential or combinational use of antivirals is increasingly being used in treatment. In this study, we introduced a multiplex restriction fragment mass polymorphism (RFMP) assay for detecting mutations...
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