Article
Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy.
Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2015
Chon Young E, Jin Bora, Ahn Sang H, Kim Seungtaek, Kim Nam D, Park Jeon H, Nam Chung M, Kim Kyun-Hwan, Hong Sun P, Choi Sung H, Kim Do Y, Park Jun Y, Han Kwang-Hyub
Abstract excerpt
BACKGROUND & AIMS: Analysing the mutation pattern of multidrug resistance (MDR) is important in the treatment of chronic hepatitis B (CHB). In this study, the evolutionary pattern of MDR mutations was investigated in patients receiving entecavir (ETV) rescue therapy. METHODS: Eight CHB patients with lamivudine (LAM)- and adefovir (ADV)-resistant mutations showing suboptimal response to ETV and to subsequent...
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