Strategies for identifying the genetic basis of dyslipidemia: genome-wide association studies vs. the resequencing of extremes.

Abstract excerpt

PURPOSE OF REVIEW: Genome-wide association studies (GWASs) and the resequencing of extremes are two methods currently being used to identify the causative variants in dyslipidemia. RECENT FINDINGS: GWASs are high-throughput, array-based platforms. They are nonhypothesis-based and scan within and across many genes. Associated variants identified via GWAS are likely to be common, have modest effect sizes, and are...

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