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Article

Missing heritability in the tails of quantitative traits? A simulation study on the impact of slightly altered true genetic models.

Human heredity - 1 Jan 2011

Pütter Carolin, Pechlivanis Sonali, Nöthen Markus M, Jöckel Karl-Heinz, Wichmann Heinz-Erich, Scherag André

Abstract excerpt

OBJECTIVE: Genome-wide association studies have identified robust associations between single nucleotide polymorphisms and complex traits. As the proportion of phenotypic variance explained is still limited for most of the traits, larger and larger meta-analyses are being conducted to detect additional associations. Here we investigate the impact of the study design and the underlying assumption about the true...

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PMID: 22041814
DOI: 10.1159/000332824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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