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Article

Genotyping by alkaline dehybridization using graphically encoded particles.

Chemistry (Weinheim an der Bergstrasse, Germany) - 1 Mar 2011

Zhang Huaibin, DeConinck Adam J, Slimmer Scott C, Doyle Patrick S, Lewis Jennifer A, Nuzzo Ralph G

Abstract excerpt

This work describes a nonenzymatic, isothermal genotyping method based on the kinetic differences exhibited in the dehybridization of perfectly matched (PM) and single-base mismatched (MM) DNA duplexes in an alkaline solution. Multifunctional encoded hydrogel particles incorporating allele-specific oligonucleotide (ASO) probes in two distinct regions were fabricated by using microfluidic-based stop-flow...

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Identifiers

PMID: 21305624
DOI: 10.1002/chem.201002848
PMCID: PMC4117403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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