Article
Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis.
PLoS genetics - 3 Feb 2011
Haataja Ritva, Karjalainen Minna K, Luukkonen Aino, Teramo Kari, Puttonen Hilkka, Ojaniemi Marja, Varilo Teppo, Chaudhari Bimal P, Plunkett Jevon, Murray Jeffrey C, McCarroll Steven A, Peltonen Leena, Muglia Louis J, Palotie Aarno, Hallman Mikko
Abstract excerpt
Preterm birth is the major cause of neonatal death and serious morbidity. Most preterm births are due to spontaneous onset of labor without a known cause or effective prevention. Both maternal and fetal genomes influence the predisposition to spontaneous preterm birth (SPTB), but the susceptibility loci remain to be defined. We utilized a combination of unique population structures, family-based linkage analysis,...
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