Article
Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth.
PLoS genetics - 1 Jul 2018
Huusko Johanna M, Karjalainen Minna K, Graham Britney E, Zhang Ge, Farrow Emily G, Miller Neil A, Jacobsson Bo, Eidem Haley R, Murray Jeffrey C, Bedell Bruce, Breheny Patrick, Brown Noah W, Bødker Frans L, Litterman Nadia K, Jiang Pan-Pan, Russell Laura, Hinds David A, Hu Youna, Rokas Antonis, Teramo Kari, Christensen Kaare, Williams Scott M, Rämet Mika, Kingsmore Stephen F, Ryckman Kelli K, Hallman Mikko, Muglia Louis J
Abstract excerpt
Preterm birth is a leading cause of morbidity and mortality in infants. Genetic and environmental factors play a role in the susceptibility to preterm birth, but despite many investigations, the genetic basis for preterm birth remain largely unknown. Our objective was to identify rare, possibly damaging, nucleotide variants in mothers from families with recurrent spontaneous preterm births (SPTB). DNA samples...
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