Article
Mapping genetic susceptibility to spontaneous preterm birth: analysis of Utah pedigrees to find inherited genetic factors.
American journal of obstetrics and gynecology - 1 Jun 2025
Workalemahu Tsegaselassie, Clark Erin A S, Madsen Michael J, Yu Zhe, Dalton Susan E, Esplin M Sean, Manuck Tracy, Neklason Deborah, Wu Chen-Han Wilfred, Jorde Lynn B, Camp Nicola J, Silver Robert M, Varner Michael W
Abstract excerpt
BACKGROUND: Spontaneous preterm birth (SPTB) is the leading cause of neonatal morbidity and mortality. It is a final common pathway for multiple etiologies, some of which are well known while others likely remain to be identified. Despite recent advancements in identifying genetic risk factors, the mechanisms of many SPTBs remain poorly understood due to the phenotypic heterogeneity and complexity. Large...
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