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Article

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

10 Feb 2011

Abstract excerpt

ABSTRACT The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the antibody-combining site and contributes to its high potency against the 1918 and 2009 pandemic H1N1 influenza...

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PMID: 21304166
DOI: 10.1128/mbio.00345-10

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