Humans in a Dish: The Potential of Organoids in Modeling Immunity and Infectious Diseases

Abstract excerpt

For many decades, human infectious diseases have been studied in immortalized cell lines, isolated primary cells from blood and a range of animal hosts. This research has been of fundamental importance in advancing our understanding of host and pathogen responses but remains limited by the absence of multicellular context and inherent differences in animal immune systems that result in altered immune responses....

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