Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome.

doi:10.1016/j.jaci.2009.05.004

Article

Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome.

The Journal of allergy and clinical immunology - 1 Aug 2009

Al Khatib Shadi, Keles Sevgi, Garcia-Lloret Maria, Karakoc-Aydiner Elif, Reisli Ismail, Artac Hasibe, Camcioglu Yildiz, Cokugras Haluk, Somer Ayper, Kutukculer Necil, Yilmaz Mustafa, Ikinciogullari Aydan, Yegin Olcay, Yüksek Mutlu, Genel Ferah, Kucukosmanoglu Ercan, Baki Ali, Bahceciler Nerin N, Rambhatla Anupama, Nickerson Derek W, McGhee Sean, Barlan Isil B, Chatila Talal

Abstract excerpt

BACKGROUND: The hyper IgE syndrome (HIES) is characterized by abscesses, eczema, recurrent infections, skeletal and connective tissue abnormalities, elevated serum IgE, and diminished inflammatory responses. It exists as autosomal-dominant and autosomal-recessive forms that manifest common and di...

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Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome.

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