Article
A dynamic model for genome-wide association studies.
Human genetics - 1 Jun 2011
Das Kiranmoy, Li Jiahan, Wang Zhong, Tong Chunfa, Fu Guifang, Li Yao, Xu Meng, Ahn Kwangmi, Mauger David, Li Runze, Wu Rongling
Abstract excerpt
Although genome-wide association studies (GWAS) are widely used to identify the genetic and environmental etiology of a trait, several key issues related to their statistical power and biological relevance have remained unexplored. Here, we describe a novel statistical approach, called functional GWAS or fGWAS, to analyze the genetic control of traits by integrating biological principles of trait formation into...
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