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Article

2HiGWAS: a unifying high-dimensional platform to infer the global genetic architecture of trait development.

Briefings in bioinformatics - 1 Nov 2015

Jiang Libo, Liu Jingyuan, Zhu Xuli, Ye Meixia, Sun Lidan, Lacaze Xavier, Wu Rongling

Abstract excerpt

Whole-genome search of genes is an essential approach to dissecting complex traits, but a marginal one-single-nucleotide polymorphism (SNP)/one-phenotype regression analysis widely used in current genome-wide association studies fails to estimate the net and cumulative effects of SNPs and reveal the developmental pattern of interplay between genes and traits. Here we describe a computational framework, which we...

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PMID: 25697399
DOI: 10.1093/bib/bbv002

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